重组人白介素15（IL-15）
产品名：重组人白介素15（IL-15）
产品号：LT0123
产品信息：
白介素15是白介素2细胞因子家族成员之一，通过Yc受体亚单位发挥生物学功能。目前已有多项针对肿瘤和血液肿瘤的治疗进入临床。白介素2与白介素15都参与早期T细胞增殖与激活。白介素15的抗肿瘤活性还来源于通过非抗原特异性方式直接激活CD8+ 效应T细胞。白介素15针对免疫细胞治疗的研究已经进入Ⅰ期临床。
别名:
IL-T
描述:
IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activities primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been linked to with rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant Human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues.
氨基酸序列:
MNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
来源:
E.coli
纯度&内毒素：
Greater than 95% by SDS-PAGE
gel and HPLC analyses.
Endotoxin Level<0.5EU/μg
生物活性：
The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 10^6 units/mg.
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