Nanolive全息无标记活细胞3D成像系统
基本信息
性能参数
Nanolive全息无标记活细胞3D成像系统
Nanolive全息无标记活细胞3D成像系统是通过无标记，非侵入式的方式，基于细胞内部折射率对细胞3D内部结构成像，最多可同时对7个不同折射率的内部结构进行数字染色，并辅以三通道的荧光用于荧光转染等分子研究，可以非常完美的解决活细胞3D内部结构研究问题，成为世界独一无二的活细胞3D结构研究工具。该技术于2013年发表在Nature上，因其操作简单，无需任何侵入式的样本准备，3D内部结构研究无需昂贵的抗体，且技术先进，一次获取的数据丰富，并且配套的Steve软件可对基于折射率的细胞内部结构做量化分析。系统上市以来受到了哈佛大学、加州大学、康奈尔大学等世界顶级科研界的顶级专家们的青睐。
产品技术特点：
1. 无标记、无损伤细胞3D内部结构成像；
2.高分辨率：xy=167nm；
3.长时间活细胞成像 ：1h—数周；
4.超快速：1.67秒钟完成细胞拍摄及3D影像构建；
5.高通量信息分析：7个数字染色+3通道荧光=10色；
6.全方位分析：全息无标记3D内部结构成像与荧光分子标记无缝整合；
7. 直观、专业的数据探索软件；
应用领域：
1. 细胞发育（如细胞分裂、细胞器的观察等）；
2. 细胞死亡、 药物研究、共培养、纳米颗粒、三维培养、全息荧光；
经典应用案例：
案例一：小鼠成纤维网状细胞
案例二：人黑色素瘤细胞凋亡
案例三：软骨细胞对药物的反应
部分引用文献：
部分引用文献：
一、2019年：
病原体与宿主研究
1. Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host InteractionFrontiers in Nutrition.2019
2. Besnoitiabesnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDLuptake in host endothelial cells Nature Scientifc Reports.2019
3. Diagnosing water treatment critical control points for cyanobacterial removal: Exploring benefts ofcombined microscopy, next-generation sequencing, and cell integrity methods Science Direct.2019
4. Superresolved and reference-free microparticle traction force microscopy (MP-TFM) reveals thecomplexity of the mechanical interaction in phagocytosis BioRxiv.2019
纳米材料研究
5. Synthesis of fuorescent molybdenum nanoclusters at ambient temperature and their application inbiological imaging Science Direct.2019
6. Antibioflm Nitric Oxide Releasing Polydopamine Coatings ACS Publications.2019
7. Nanoparticles Based on Poly(trimethylene carbonate) Triblock Copolymers with Post-CrystallizationAbility and Their Degradation in vitro Macromolecular Research.2019
癌症研究
8. Pleiotropic Efects of Epithelial Mesenchymal Crosstalk on Head and Neck Cancer: EMT and beyond Cancer Microenvironment. 2019
9. BA6 Induces Apoptosis via Stimulation of Reactive Oxygen Species and Inhibition of Oxidative hosphorylation in Human Lung Cancer Cells.2019
线粒体与凋亡研究
10. Quantifcation of changes in cellular morphology during cell necrosis obtained from 3D refractive index distributions Journal of Physics.2019
11. Endocytosis-mediated mitochondrial transplantation: Transferring normal human astrocytic mitochondria into glioma cells rescues aerobic respiration and enhances radiosensitivity Theranostics IF 8.0.2019
12. Methamphetamine-induced apoptosis in glial cells examined under markerfree imaging modalities Journal of Biomedical Optics.2019
13. Degradation of Mitochondria and Oxidative Stress as the Main Mechanism of Toxicity of Pristine Graphene on U87 Glioblastoma Cells and Tumors and HS-5 Cells Publishing International Journal of Molecular Sciences.2019
二、2018年：
14. Enhancing the antimicrobial and antibioflmefectiveness of silver nanoparticles prepared by greensynthesis Journal of Materials Chemistry B 2018, IF 9.9.2018
15. Nitric Oxide-Loaded Antimicrobial Polymer for the Synergistic Eradication of Bacterial BioflmASC Macro Letter .2018
16. Live-stream characterization of cadmium-induced cell death using visible CdTe-QDsScientifc reports IF4.1.2018
药物研究
17. The selexipag active metabolite ACT-333679 displays strong anti-contractile and anti- remodelingefects, but low β-arrestin recruitment and desensitization potential.2018
癌症研究
18. Morphological changes in the ovarian carcinoma cells of Wistar rats induced by chemotherapy.2018
线粒体与凋亡研究
19. Parvalbumin alters mitochondrial dynamics and afects cell morphology Cellular and Molecular Life Sciences. 2018
干细胞研究
20. Label free 3D analysis of organelles in living cells by refractive index shows pre-mitotic organelle spinning in mammalian stem cells BioRxiv.2018
其它研究
21. Label-free digital holo-tomographic microscopy reveals virus-induced cytopathic efects in live cells BioRxiv. 2018
22. Characterising live cell behaviour: Traditional label-free and quantitative phase imaging approaches。2018
三、2017年：
病原体与宿主研究
23. The Efects of Polymer Topology and Chain Length on the Antimicrobial Activity andHemocompatibility of Amphiphilic Ternary Copolymers Polymer Chemistry， 2017
纳米材料研究
24. Facile preparation of full-color emissive carbon dots and their applications in imaging of the adhesion of erythrocytes to endothelial cells Journal of Materials Chemistry B ，2017
药物研究
25. The Journal of Pharmacology and Experimental Therapeutics, 2017
26. The International Journal of Biochemistry & Cell Biology, 2017
四、2016年：
癌症研究
27. Live Single-cell Mass Spectrometry with Spatial Quantitation by Three-Dimensional Holographic and Tomographic Laser Microscopy Analytical Sciences 2016
2. Besnoitiabesnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDLuptake in host endothelial cells Nature Scientifc Reports.2019
3. Diagnosing water treatment critical control points for cyanobacterial removal: Exploring benefts ofcombined microscopy, next-generation sequencing, and cell integrity methods Science Direct.2019
4. Superresolved and reference-free microparticle traction force microscopy (MP-TFM) reveals thecomplexity of the mechanical interaction in phagocytosis BioRxiv.2019
纳米材料研究
5. Synthesis of fuorescent molybdenum nanoclusters at ambient temperature and their application inbiological imaging Science Direct.2019
6. Antibioflm Nitric Oxide Releasing Polydopamine Coatings ACS Publications.2019
7. Nanoparticles Based on Poly(trimethylene carbonate) Triblock Copolymers with Post-CrystallizationAbility and Their Degradation in vitro Macromolecular Research.2019
癌症研究
8. Pleiotropic Efects of Epithelial Mesenchymal Crosstalk on Head and Neck Cancer: EMT and beyond Cancer Microenvironment. 2019
9. BA6 Induces Apoptosis via Stimulation of Reactive Oxygen Species and Inhibition of Oxidative hosphorylation in Human Lung Cancer Cells.2019
线粒体与凋亡研究
10. Quantifcation of changes in cellular morphology during cell necrosis obtained from 3D refractive index distributions Journal of Physics.2019
11. Endocytosis-mediated mitochondrial transplantation: Transferring normal human astrocytic mitochondria into glioma cells rescues aerobic respiration and enhances radiosensitivity Theranostics IF 8.0.2019
12. Methamphetamine-induced apoptosis in glial cells examined under markerfree imaging modalities Journal of Biomedical Optics.2019
13. Degradation of Mitochondria and Oxidative Stress as the Main Mechanism of Toxicity of Pristine Graphene on U87 Glioblastoma Cells and Tumors and HS-5 Cells Publishing International Journal of Molecular Sciences.2019
二、2018年：
14. Enhancing the antimicrobial and antibioflmefectiveness of silver nanoparticles prepared by greensynthesis Journal of Materials Chemistry B 2018, IF 9.9.2018
15. Nitric Oxide-Loaded Antimicrobial Polymer for the Synergistic Eradication of Bacterial BioflmASC Macro Letter .2018
16. Live-stream characterization of cadmium-induced cell death using visible CdTe-QDsScientifc reports IF4.1.2018
药物研究
17. The selexipag active metabolite ACT-333679 displays strong anti-contractile and anti- remodelingefects, but low β-arrestin recruitment and desensitization potential.2018
癌症研究
18. Morphological changes in the ovarian carcinoma cells of Wistar rats induced by chemotherapy.2018
线粒体与凋亡研究
19. Parvalbumin alters mitochondrial dynamics and afects cell morphology Cellular and Molecular Life Sciences. 2018
干细胞研究
20. Label free 3D analysis of organelles in living cells by refractive index shows pre-mitotic organelle spinning in mammalian stem cells BioRxiv.2018
其它研究
21. Label-free digital holo-tomographic microscopy reveals virus-induced cytopathic efects in live cells BioRxiv. 2018
22. Characterising live cell behaviour: Traditional label-free and quantitative phase imaging approaches。2018
三、2017年：
病原体与宿主研究
23. The Efects of Polymer Topology and Chain Length on the Antimicrobial Activity andHemocompatibility of Amphiphilic Ternary Copolymers Polymer Chemistry， 2017
纳米材料研究
24. Facile preparation of full-color emissive carbon dots and their applications in imaging of the adhesion of erythrocytes to endothelial cells Journal of Materials Chemistry B ，2017
药物研究
25. The Journal of Pharmacology and Experimental Therapeutics, 2017
26. The International Journal of Biochemistry & Cell Biology, 2017
四、2016年：
癌症研究
27. Live Single-cell Mass Spectrometry with Spatial Quantitation by Three-Dimensional Holographic and Tomographic Laser Microscopy Analytical Sciences 2016
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