多功能圆二色光谱仪Chirascan™系列
基本信息
产品名称：
多功能圆二色光谱仪Chirascan™系列
英文名称：
Chirascan™ Circular Dichroism Spectrometer
国产/进口：
进口
产地/品牌：
英国应用光物理公司
型号：
Chirascan™
参考报价：
询价
销售商：
总点击数：
62650
更新日期：
2024-10-11
产品类别：
性能参数
简单介绍
Chirascan plus圆二色光谱仪可以在温度变化的同时得到全波长范围的圆二色谱、紫外吸收光谱、荧光光谱、相变温度Tm、相变的热力学焓变△H 等多维度的表征参数， 从而判断生物大分子的结构、稳定性、药物体系的组方优化和筛选。通过体系的CD变化与温度变化的相关关系而得到的构象变化信息， 比微量量热学的表达更灵敏、分辨更清晰。 一次实验得到多维信息， 节省实验时间及样品。CD
多功能圆二色光谱仪详细介绍
技术参数
Chirascan plus型号圆二色光谱仪， 可以在温度变化的同时得到全光谱的圆二色光谱（CD谱）、紫外吸收谱、荧光谱、相变温度Tm、相变的热力学焓变△H 等多维度的表征参数， 从而判断生物大分子的结构、稳定性、药物体系的组方优化和筛选，在分子水平上解释生物大分子相互作用的机理和原因，生物大分子的构象变化，属国际前沿技术和方法。通过体系的圆二色光谱（CD）变化与温度变化的相关关系而得到的构象变化信息， 比微量量热学的表达更灵敏、分辨更清晰。 在药物体系组方筛选、蛋白折叠等研究方向已经广为使用， 一次实验得到多维信息， 节省实验时间及样品。
Lead optimisation
·Protein engineering
·Small & large drug binding
·Membrane studies
·Formulation and stability testing
·Biocomparability & quality control
·Sructure activity relationship (SAR) studies
光源 Light Source: 150W Xe (air cooled) 氙灯。
光通量 light throughput:≥1.5 x 1013 photons/sec (at 180nm， 1nm bandwidth)
波长范围 Standard Wavelength Range: 160nm to 1100nm
波长准确度 Wavelength Accuracy: ±0.1nm (170nm – 400nm)
± 0.5nm (400nm – 900nm)
波长重复性 Wavelength Repeatability： ±0.05 nm(163~400 nm)
±0.1nm((> 400nm)
波长分辨率Wavelength Resolution: 0.1nm 全波长范围
光谱狭缝带宽 Slit Bandwidth: 0 to 2nm at 160nm (in 0.1nm increments)
0 to 4nm at 180nm (in 0.1nm increments)
0 to 12nm above 222nm (in 0.1nm increments)
扫描模式 Scanning Modes: Fixed Sampling, Adaptive Sampling 自动优化数据采集
氮气吹扫 Nitrogen Purging: Unique sealed design for rapid purge and minimal
nitrogen consumption
启动时间 Startup: <15mins
吹扫气体用量 Purge Gas Requirements: 5 l/min (全波长)， 2 l/min > 200nm
杂散光 Stray Light: < 2 ppm at 200nm
< 5 ppm at 180nm
CD 噪音水平 CD RMS Noise:
|
0.030mº @ 175nm
0.010mº @ 185nm
0.020mº @ 200nm
0.020mº @ 500nm
(2 second oversampling, 1nm b/w)
|
基线稳定性 Baseline Stability: < 0.02mº/hour
公司简介
英国应用光物理公司Applied Photophysics Ltd----世界知名的专业仪器制造商, 圆二色光谱仪、停流Stopped flow 反应动力学分析仪、激光闪解Laser Flash Photolysis 分析仪等广泛应用于分子结构、分子间相互作用、动力学分析等领域的研究，特别是生物大分子、生物大分子与小分子如药物、各类手性化合物等的结构与相互作用的研究。
CD Chirascan 圆二色CD光谱仪为静态圆二色光谱分析树立了新的标准，它采用多种新技术、新设计，使光强度达到最大，特别是远紫外区。它的先进、精密的数字式数据采集系统可实现快速、准确的光谱采集。
可配置多种扩展功能模块（吸收、荧光、全荧光谱、荧光偏振各向异性谱、磁CD、ORD （旋光色散）、低温检测附件、滴定系统、停流Stopped flow 系统等），以使各种研究目的都能得到高质量的、可靠的、可验证的结果数据。有大量高水平的科研论文和基础研究成果的数据出自本系列仪器。在药物研发、药物筛选等基础应用研究上是常用的基本的研究工具，知名制药公司如GSK, 阿斯利康、诺和诺德、礼莱、罗氏，Amgen等均有多台本系列仪器在各个研究组发挥着重要的作用。
英国 Applied Photophysics Ltd ( 应用光物理公司) 生产的型号为 Chirascan 的圆二色CD(circular dichroism) 光谱仪，在国内的清华大学、北京大学、武汉大学、中山大学、四川大学、重庆大学、南京大学、哈尔滨工业大学、华南农业大学、山东大学、郑州大学等的著名实验室有很好的应用，在中科院生物物理所、中科院微生物所、中科院天津生物技术所、中科院上海应用物理所、中科院上海有机化学所、中科院上海药物研究所、中科院武汉病毒所、中科院武汉物理与数学研究所、中科院苏州纳米所、中科院南海海洋研究所等多个学科方向的实验室在使用中， 并有很好的高等级的文献引用和发表。
CD光谱仪 Chirascan qCD and Chirascan-plus qCD Circular Dichroism Spectrometers
Chirascan and Chirascan-plus are the world's most advanced circular dichroism (CD) spectrometers. They are widely used in the study of the higher structures of bio-macromolecules, such as proteins and DNA, and how these structures change on interaction with other molecular entities. Their many innovative features provide the scientist with easy-to-use, productive tools that deliver circular dichroism spectra of a quality and on a timescale that has until recently been impossible.
停流（stopped flow）技术,用于研究溶液体系的非常快速的反应的机理,反应的时间一般在0.001秒到0.01秒之间,通过研究瞬时动力学现象可反映反应的速度、机理、短时间存在过的反应中间体等基础信息。英国 Applied Photophysics Ltd ( 应用光物理公司) 生产的型号为 SX20 系列的停流光谱仪，数据引用率占可检索到的已发表的文献的八成以上。可选择配置的功能模块为：时间分辨的吸收分析、二极管阵列检测器、双荧光检测、荧光偏振检测，多通道序列混合系统、淬灭停流检测，及CD圆二色停流分析系统等
SX20 停流光谱仪 SX20 Stopped-Flow Spectrometer
The SX20 is the latest in the SX range of stopped-flow reaction analysers from Applied Photophysics and is used to study transient and pre-steady-state kinetics of fast, liquid-phase reactions. The SX range has, since its introduction over 15 years ago, established itself as the first choice of those involved in stopped-flow kinetic research. The SX20 and its predecessors offer unrivalled performance, as well as a host of upgrade opportunities for the detailed investigation of chemical and biochemical reaction mechanisms.
RX.2000 快速混合停流装置，可与各种型号的紫外可见分光光度计（如Agilent 8453, 瓦里安 Cary 50,100, 300 等）、荧光光谱仪（如日立 Hitachi 荧光 F-4000, F-4500, F-4600, F-7000等各型号荧光光谱仪,PE各型号荧光光谱仪等）、CD光谱仪联用，研究毫秒级的快速动力学反应。小巧方便，经济适用。
SX20 停流光谱仪 SX20 Stopped-Flow Spectrometer
The SX20 is the latest in the SX range of stopped-flow reaction analysers from Applied Photophysics and is used to study transient and pre-steady-state kinetics of fast, liquid-phase reactions. The SX range has, since its introduction over 15 years ago, established itself as the first choice of those involved in stopped-flow kinetic research. The SX20 and its predecessors offer unrivalled performance, as well as a host of upgrade opportunities for the detailed investigation of chemical and biochemical reaction mechanisms.
RX.2000 快速混合停流装置，可与各种型号的紫外可见分光光度计（如Agilent 8453, 瓦里安 Cary 50,100, 300 等）、荧光光谱仪（如日立 Hitachi 荧光 F-4000, F-4500, F-4600, F-7000等各型号荧光光谱仪,PE各型号荧光光谱仪等）、CD光谱仪联用，研究毫秒级的快速动力学反应。小巧方便，经济适用。
RX.2000 Rapid Mixing Stopped-Flow Unit
The RX.2000 provides the means to measure stopped-flow rapid reaction kinetics using any UV-visible spectrometer, fluorometer or CD spectropolarimeter. This high performance, cost effective unit enables reactions to be studied that are at least a thousand fold faster than those accessible manually.
纳秒级激光光闪解分析仪LKS.80 Nanosecond Laser Photolysis Spectrometer，用于纳秒、微妙时间范围内的动力学分析，包含时间分辨光谱分析，灵敏度高，响应时间短。
Applied Photophysics has been supplying laser flash-photolysis instruments since 1973. The experience gained during this period has resulted in the LKS.60 spectrometer which offers both ease of use and flexibility, including special configurations such as combined stopped-flow and/or flow-flash systems. The LKS.60 is used to study the reactions of very short-lived species, such as free radicals or excited state species
The RX.2000 provides the means to measure stopped-flow rapid reaction kinetics using any UV-visible spectrometer, fluorometer or CD spectropolarimeter. This high performance, cost effective unit enables reactions to be studied that are at least a thousand fold faster than those accessible manually.
纳秒级激光光闪解分析仪LKS.80 Nanosecond Laser Photolysis Spectrometer，用于纳秒、微妙时间范围内的动力学分析，包含时间分辨光谱分析，灵敏度高，响应时间短。
Applied Photophysics has been supplying laser flash-photolysis instruments since 1973. The experience gained during this period has resulted in the LKS.60 spectrometer which offers both ease of use and flexibility, including special configurations such as combined stopped-flow and/or flow-flash systems. The LKS.60 is used to study the reactions of very short-lived species, such as free radicals or excited state species
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