N-乙酰-L-胱氨酸
基本信息
产品名称：
N-乙酰-L-胱氨酸
英文名称：
N-acetylcysteine amide
国产/进口：
进口
产地/品牌：
美国/TargetMol
型号：
参考报价：
面议
销售商：
总点击数：
7029
更新日期：
2025-10-30
产品类别：
性能参数
Product Introduction
Bioactivity
英文名: N-acetylcysteine amide
描述: N-Acetylcysteine amide 是一种硫醇抗氧化剂，也是一种神经保护剂，能够透过细胞膜和血脑屏障的，可降低ROS 的产生。
细胞实验: To determine effectiveness of NACA and NAC in protection of H9c2 cells from DOX-induced toxicity, cells were treated with NACA or NAC at 0.75 mM for 2 h followed by exposure to freshly prepared cell culture medium with DOX in presence or absence of NACA or NAC at designated concentrations. The concentrations of DOX were 0.25 μM, 0.75 μM, 2 μM, 5 μM, 20 μM, and 100 μM. The exposure durations were 24 h, 48 h, or 48 h. Cells incubated with NACA or NAC alone were used as the control[1].
动物实验: rats were randomly divided into three groups (n=6-8 animals/group): N-acetylcysteine amide?loaded pump (18.5?mg/kg/hr) and a single 150 mg/kg bolus intraperitoneal (IP) injection of NACA given (30 min post-injury) ?N-acetylcysteine amide?(18.5 mg/kg/hr) loaded pump and a single 150 mg/kg bolus injection of N-acetylcysteine amide?given IP (30 min post-injury) ?Vehicle loaded pump and?single vehicle bolus injection given IP (30 min post-injury).?Following random distribution of all animals into one of the three previous groups, experimenters were blinded to treatment group.?The osmotic mini pumps were assembled and implanted immediately after injury and remained in the animals for 7 days[2]
体外活性: Although NACA effectively reduced oxidative stress in DOX-treated H9c2 cells, it had minimal effects on DOX-induced cell death.?NACA prevented oxidative stress by elevation of GSH and CYS, reduction of ROS and lipid peroxidation, and restoration of antioxidant enzyme activities[1].
体内活性: N-acetylcysteine amide reduces cortical tissue damage and decreases the distance traveled to the platform in the Morris water maze in a rat model of traumatic brain injury[2].N-acetylcysteine amide (60 and 120 mg/kg) also inhibits ovalbumin-induced decreases in GSH, increases in nuclear NF-κB p65 and HIF-1α, and increases in IL-4, IL-5, and IL-13 levels in mouse lung tissue[3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55 mg/mL (339.07 mM)
关键字: Nacetylcysteine amide | N acetylcysteine amide | Reactive Oxygen Species | inhibit | N-Acetylcysteine amide | Inhibitor | N-acetylcysteine Amide
相关产品: Nitisinone | L-Glutathione reduced | H2DCFDA | Tempo | Sodium dichloroacetate | Procyanidin B2 | OPC-163493 | Epiberberine chloride | Diphenyleneiodonium chloride | Cyfluthrin
相关库: Drug Repurposing Compound Library | Oxidation-Reduction Compound Library | Anti-Cancer Drug Library | Bioactive Compounds Library Max | CNS-Penetrant Compound Library | Anti-Cancer Clinical Compound Library | Anti-Obesity Compound Library | Anti-Fibrosis Compound Library | Cuproptosis Compound Library | NO PAINS Compound Library
Bioactivity
英文名: N-acetylcysteine amide
描述: N-Acetylcysteine amide 是一种硫醇抗氧化剂，也是一种神经保护剂，能够透过细胞膜和血脑屏障的，可降低ROS 的产生。
细胞实验: To determine effectiveness of NACA and NAC in protection of H9c2 cells from DOX-induced toxicity, cells were treated with NACA or NAC at 0.75 mM for 2 h followed by exposure to freshly prepared cell culture medium with DOX in presence or absence of NACA or NAC at designated concentrations. The concentrations of DOX were 0.25 μM, 0.75 μM, 2 μM, 5 μM, 20 μM, and 100 μM. The exposure durations were 24 h, 48 h, or 48 h. Cells incubated with NACA or NAC alone were used as the control[1].
动物实验: rats were randomly divided into three groups (n=6-8 animals/group): N-acetylcysteine amide?loaded pump (18.5?mg/kg/hr) and a single 150 mg/kg bolus intraperitoneal (IP) injection of NACA given (30 min post-injury) ?N-acetylcysteine amide?(18.5 mg/kg/hr) loaded pump and a single 150 mg/kg bolus injection of N-acetylcysteine amide?given IP (30 min post-injury) ?Vehicle loaded pump and?single vehicle bolus injection given IP (30 min post-injury).?Following random distribution of all animals into one of the three previous groups, experimenters were blinded to treatment group.?The osmotic mini pumps were assembled and implanted immediately after injury and remained in the animals for 7 days[2]
体外活性: Although NACA effectively reduced oxidative stress in DOX-treated H9c2 cells, it had minimal effects on DOX-induced cell death.?NACA prevented oxidative stress by elevation of GSH and CYS, reduction of ROS and lipid peroxidation, and restoration of antioxidant enzyme activities[1].
体内活性: N-acetylcysteine amide reduces cortical tissue damage and decreases the distance traveled to the platform in the Morris water maze in a rat model of traumatic brain injury[2].N-acetylcysteine amide (60 and 120 mg/kg) also inhibits ovalbumin-induced decreases in GSH, increases in nuclear NF-κB p65 and HIF-1α, and increases in IL-4, IL-5, and IL-13 levels in mouse lung tissue[3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55 mg/mL (339.07 mM)
关键字: Nacetylcysteine amide | N acetylcysteine amide | Reactive Oxygen Species | inhibit | N-Acetylcysteine amide | Inhibitor | N-acetylcysteine Amide
相关产品: Nitisinone | L-Glutathione reduced | H2DCFDA | Tempo | Sodium dichloroacetate | Procyanidin B2 | OPC-163493 | Epiberberine chloride | Diphenyleneiodonium chloride | Cyfluthrin
相关库: Drug Repurposing Compound Library | Oxidation-Reduction Compound Library | Anti-Cancer Drug Library | Bioactive Compounds Library Max | CNS-Penetrant Compound Library | Anti-Cancer Clinical Compound Library | Anti-Obesity Compound Library | Anti-Fibrosis Compound Library | Cuproptosis Compound Library | NO PAINS Compound Library
公司简介
TargetMol（陶术）作为一家全球性的生物医药领域高科技企业，我们致力于为高校、研究所、医院、企业等各类生物医药研发机构提供优质的产品和服务，为全球医药科学家更高效地完成科研工作助力。可提供20,000+种 抑制剂和激动剂 、800+种 化合物库 、19,000+种 天然产物 ，以及9,000+种 重组蛋白 、多种 多肽 、抗体 和 生命科学试剂盒 等。此外，在上海，TargetMol研发中心配备了 CADD & AIDD研究中心、药理实验室和药物化学合成 平台三大技术中心，可提供虚拟筛选、化合物活性测试、分子间结合力检测和化合物结构优化等技术服务，多方位满足用户的研发需求。
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