肿瘤模型
Pharmatest offers full-service efficacy testing of new cancer drug candidates. Pharmatest’s strategy is to offer in vitro cancer cell cultures and clinically predictive animal models with the same cancer cell lines. The in vitro studies will demonstrate what cancer cell lines are affected by the test compounds, and the efficacy is then confirmed in vivo with the animal models. This strategy will save time and costs for our customers and reduce the amount of animal experiments needed.
Pharmatest is specialized in orthotopic and metastasis models of breast, prostate and pancreatic cancer and multiple myeloma. The major advantage of these models is the proper tissue microenvironment that is known to affect tumor growth, metastasis and drug resistance. This increases substantially the clinical relevance and predictivity over traditionally used subcutaneous models that lack the proper microenvironment. The table below summarizes the orthotopic and metastasis models that are currently available in Pharmatest.
Tissue | Cell Line | Property | Type | Route | Metastasis |
Breast | MDA-MB-231(SA)* | Triple-negative | Xenograft | Intracardiac | Bone |
Orthotopic | Lung, Lymph nodes | ||||
4T1* | Triple-negative | Syngeneic | Intracardiac | Bone | |
Orthotopic | Lung, Liver, Lymph nodes | ||||
MCF-7 | ER+ | Xenograft | Orthotopic | None | |
BT474 | Triple-positive | Xenograft | Intratibial | Bone | |
Prostate | PC-3 | AR- | Xenograft | ||
Intratibial | Bone | ||||
Orthotopic | Lymph nodes | ||||
LNCaP | AR+, PSA+ | Xenograft | Intratibial | Bone | |
Orthotopic | None | ||||
VCaP | AR+, PSA+ | Xenograft | Intratibial | Bone | |
Pancreas | BxPC3** | Xenograft | Orthotopic | None | |
Blood/Multiple myeloma | 5TGM1 | Syngeneic | Tail vein | Bone |
*Available with GFP label
**Available with luciferace label
All cancer cell lines listed above are also available for in vitro cancer cell culture assays and subcutaneous animal models, as are some other cancer cell lines without validated orthotopic or metastasis models that can be found here.
If your focus is on cancer bone metastases, we would also like to invite you to take a look at our in vitro osteoclast assays that are useful for testing novel cancer drug compounds targeting osteoclasts to inhibit the vicious cycle of cancer-induced bone disease.
广东固康生物科技有限公司是一家专业从事体外诊断试剂研发和销售的高科技企业,通过发现市场需求来引导产品开发及引进,从而更好地服务于市场。现公司在全国(包括香港和澳门地区)均有销售网络,并在北京、南京、济南、郑州、天津等地设立了销售中心。
公司主营产品有骨代谢系列试剂、软骨分析试剂、传染病(呼吸道和消化道)系列试剂、肿瘤系列试剂、生殖道检测系列试剂、心血管系列检测试剂、体外诊断试剂原料和抗体抗原等。此外,公司还同时提供骨相关疾病动物模型及药物筛选服务,成为国内骨代谢标志物科研(临床前研究和临床研究)、临床应用(全套解决方案)的专业服务商。
公司先后成为英国IDS公司(全球领先骨代谢和软骨分析标志物生产商)、以色列SAVYON公司(全球领先传染病检测试剂生产商)、西班牙CERTEST公司、芬兰Pharmatest公司(临床前委托研究:骨质疏松症-肿瘤-骨关节炎)、奥地利BIOMEDICA集团、以色列NUCLEIX、以色列PRONTO公司、美国PROLIANT公司(新西兰牛血清白蛋白产品)、美国IMMUNOREAGENTS公司、德国IMMUDIAGNOSTIK公司、德国MEDIAGNOST公司、美国QUIDEL公司、美国IMMUTOPICS等公司的中国代理商。
公司直接从国外进口产品,缩短国外产品到达最终用户的中间环节及时间,以确保用户快速用上国外高品质的产品。对于有温度要求的产品, 提供全程温控解决方案,让用户后顾无忧!
此外,公司还将进一步引进国内外最先进技术和产品,协助促进中国医疗诊断装备和水平,从而提高国民疾病预防和预后能力。
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