【SAM-P8小鼠SAM-P8mice快速老化小鼠模型】
SAMP8小鼠、SAMR1小鼠部分用户：宁夏医科大学、中国中医科学院、同济医院、中科院遗传与发育研究所、北京师范大学、国家体育总局体育科学研究所、武汉体育大学、河北医科大学，中国医科大学、山东大学、齐鲁医院、复旦大学、瑞金医院、中科院上海药物研究所、上海交通大学、第二军医大学、第四军医大学、中科院生物物理所、南方医科大学、武汉协和、中国医学科学院等均使用本单位提供动物进行研究
SPF级SAMP8小鼠samp8mice快速老化小鼠销售价格优惠，SPF级SAMR1小鼠samp8mice快速老化小鼠销售价格优惠，保质保量，提供质量合格证，可送货到实验室
STRAIN NAME: Senescence accelerated mouse/prone8
TYPE: Spontaneous mutation
BACKGROUND STRAIN: AKR/J
COAT COLOR: White (Albino)
ORIGIN: In 1968, the United States (Bar Harber ME) Jackson laboratory presented to a few of the AKR / J mice the in Kyoto, Japan (Kyoto) University,.in Feeding and breeding process, Takeda found several mice showed different degrees epilation, rough skin, cataracts, behavioral disorders and shortened survival phenomena and have a genetic predisposition. In 1975, they carefully selected the five nest obvious aging AKR / J mice as the P series ancestors, normal aging process of mice as the R line ancestor. Select the P series, R series main criteria for degree of aging (in 8 mon degree of aging), survival period and pathological changes based on diseases associated with aging. According to the survival curve (Gompertzian function) and degree of aging get P series mice as rapid aging [1]. Therefore, P series called senescence accelerated mouse (Senescence accelerated mouse / prone, SAMP), R series known as the anti-senescence accelerated mouse.
Biology: SAMP 8 brain have a large number of Aβ deposition in the aging process. Northern hybridization analysis showed that, β-amyloid precursor protein (APP) mRNA expression did not change significantly. SAMP 8 occurred learning, memory dysfunction and Neurotransmitter change in the brain during the aging, such as the cerebral cortex and hippocampus of acetylcholine (Ach), norepinephrine (NE), dopamine (DA) and opioid peptides reduce, γ-aminobutyric acid (GABA) increased, 5 - hydroxytryptamine (5-HT) showed first increased and then decreased and so on. SAMP 8 at 2 mon occurs immune dysfunction ,the sheep red blood cells (SRBC)-induced spleen cell antibody response, Con A-induced lymphocyte proliferation and IL-2 production capacity decreased significantly. Further study found that SAMP8 CD+4 cells decreased and function decline in the spleen, NK cells normal. NK cell activity was significantly enhanced After using immunostimulants, NK cell activity decreased possible relate with IL-2 levels decline.
RESEARCH APPLICATION: learning and memory dysfunction, Evaluation of anti-aging and improve learning and memory drugs
SAMP8小鼠快速老化小鼠SAMR1小鼠
至善健康医学研究院成立于2005年，专业从事胚胎干细胞、分子生物医学及基因工程动物模型敲除的技术研发、大鼠小鼠Morris水迷宫实验外包服务及大鼠小鼠海马侧脑室aav病毒立体定位注射动物实验服务，视网膜玻璃体定位注射实验服务，分子生物医学科研动物病理生理实验外包动物病理医学科研实验外包技术服务，提供老年老龄sd大鼠及c57老年小鼠，设有干细胞生物学、分子生物学和基因工程动物表型分析实验室，可提供用于科学研究和药物研发的各类动物胚胎干细胞和人胚胎干细胞、成体细胞、基因工程干细胞株、脐带间充质干细胞、SD大鼠骨髓间充质干细胞、小鼠骨髓间充质干细胞及相关培养基，同时提供基因敲除小鼠订购、转基因小鼠订购、基因沉默小鼠和转基因小鼠等基因工程动物模型的构建和基于干细胞的药物研发服务。
随业务范围的扩大，公司面向海内外征集细胞生物学与分子生物学相关产品的合作伙伴。 经营范围：基因敲除小鼠模型建立、销售基因敲除小鼠、销售转基因小鼠、显微注射、基因打靶、条件性敲除、定点敲除转基因载体、基因沉默（siRNA）和质粒DNA表达载体构建实验技术服务；胚胎干细胞培养和细胞生物学实验服务；基因敲除小鼠、基因沉默小鼠和转基因小鼠构建；各种细胞株（人胚胎干细胞、小鼠胚胎干细胞、iPS细胞、成体干细胞和肿瘤细胞）；细胞培养基；质粒载体；超纯水、双蒸水、去离子水、医用蒸馏水销售小鼠基因敲除小鼠服务价格，RNA干扰载体构建技术服务，人胚胎干细胞、小鼠胚胎干细胞培养技术服务，基因沉默小鼠构建技术服务，siRNA载体构建技术服务，基因沉默构建技术服务，载体构建技术服务，RNAi表达载体构建服务，转基因小鼠构建，细胞生物学技术服务，分子生物学技术服务， pcDNA载体构建实验服务，siRNA质粒载体构建服务，细胞转染技术服务。
经营范围：出售销售小鼠骨髓间充质干细胞、出售销售大鼠骨髓间充质干细胞，出售销售脐带间充质干细胞，基因敲除载体、转基因载体、基因沉默（siRNA）和质粒DNA表达载体构建实验技术服务；胚胎干细胞培养和细胞生物学实验服务；基因敲除小鼠、基因沉默小鼠和转基因小鼠构建；各种细胞株（人胚胎干细胞、小鼠胚胎干细胞、iPS细胞、成体干细胞和肿瘤细胞）；细胞培养基；质粒载体；基因敲除载体、转基因载体、基因沉默载体构建小鼠、siRNA质粒载体构建、RNA载体构建实验技术服务、RNAi载体构建实验技术服务、DNA表达载体构建实验技术服务；胚胎干细胞培养和细胞生物学实验服务；基因敲除小鼠、基因沉默小鼠和转基因小鼠构建；
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