GTP酶：是GTP/GDP结合蛋白，被细胞表面受体(GPCR)激活后, 它能调节下游效应器的功能。

它可以结合GTP、水解GTP，因此在激活的GTP结合状态和非激活的GDP结合状态之间切换。

它具有内在的GTP酶活性，可将GTP水解为GDP，从而使G蛋白失活。我们精心筛选的小鼠单克隆抗体能捕捉到与GTP结合的具有活性的GTP酶。它们已被用于通过免疫组织化学监测细胞和组织中 G 蛋白的活化和分布。

武汉费斯德Rac-GTP 小鼠单抗文献更新：

002. BKM120 alters the migration of doublecortin-positive cells in the dentate gyrus of mice
Pharmacol Res. 2022 PMID: 35460881a

003. Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity
Neuron. 2022 PMID: 36323321a

004. Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis
J Cell Commun Signal. 2022 PMID: 36284029a

005. Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor
Eur Respir J. 2022 PMID: 36265882a

006. ARHGEF15 in Sertoli cells contributes to germ cell development and testicular immune privilege
Biol Reprod. 2022 PMID: 36001358a

007. Rac1 mediates cadherin-11 induced cellular pathogenic processes in aortic valve calcification
Cardiovasc Pathol. 2022 PMID: 35074515a

008. Endothelial Poldip2 regulates sepsis-induced lung injury via Rho pathway activation
Cardiovasc Res. 2022 PMID: 34528082a

009. IGF2BP2 promotes gastric cancer progression by regulating the IGF1R-RhoA-ROCK signaling pathway
Cell Signal. 2022 PMID: 35306138a

010. Long-term exposure to low concentrations of MC-LR induces blood-testis barrier damage through the RhoA/ROCK pathway
Ecotoxicol Environ Saf. 2022 PMID: 35367887a

011. ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42
J Exp Clin Cancer Res. 2022 PMID: 35869555a

012. Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcoma

001. CD16+ fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibitionCancer Cell. 2022 PMID: 36379207

002. BKM120 alters the migration of doublecortin-positive cells in the dentate gyrus of micePharmacol Res. 2022 PMID: 35460881

003. Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivityNeuron. 2022 PMID: 36323321

004. Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasisJ Cell Commun Signal. 2022 PMID: 36284029

005. Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftorEur Respir J. 2022 PMID: 36265882

006. ARHGEF15 in Sertoli cells contributes to germ cell development and testicular immune privilegeBiol Reprod. 2022 PMID: 36001358

007. Rac1 mediates cadherin-11 induced cellular pathogenic processes in aortic valve calcificationCardiovasc Pathol. 2022 PMID: 35074515

008. Endothelial Poldip2 regulates sepsis-induced lung injury via Rho pathway activationCardiovasc Res. 2022 PMID: 34528082

009. IGF2BP2 promotes gastric cancer progression by regulating the IGF1R-RhoA-ROCK signaling pathwayCell Signal. 2022 PMID: 35306138

010. Long-term exposure to low concentrations of MC-LR induces blood-testis barrier damage through the RhoA/ROCK pathwayEcotoxicol Environ Saf. 2022 PMID: 35367887

011. ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42J Exp Clin Cancer Res. 2022 PMID: 35869555

012. Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcomaNat Commun. 2022 PMID: 35484119